发给老马备查:
" u* D1 Z) t7 E" X( p1 F滴水察海(69304838) 15:23:239 J$ k0 q4 E9 H# q, ^5 y9 ~8 z
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱: U# a, o: j" ?/ F) \, o+ T
吉非替尼和S-1连用的依据
0 \! u' s0 j" UGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
% S: `0 ?+ n; N- p! M是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
" O3 p2 s( {! h+ j2 J& S这样是不是推理出,耐药后,可以用S-1和培美了?
' m4 o X- e/ H3 r7 G- g' j9 W结论:
& S: S% V1 s( s r如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |