发给老马备查:
1 S4 } N1 t2 ] c滴水察海(69304838) 15:23:23
/ B, ]: F9 L# x0 B: Q老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
5 u8 V, {. j2 n: L吉非替尼和S-1连用的依据# U" U d [: f7 O T
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
; P- {3 k/ ~" w是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达8 R5 f6 J5 J0 A" H2 |
这样是不是推理出,耐药后,可以用S-1和培美了?
* G5 B8 s/ R8 c/ J1 ]( A结论:3 P# A" }3 c. |
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |